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These changes reflect an important role of the ROFA in segregation of function during childhood.
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A large body of work in polarized epithelial cells has shown the segregation of proteins to the basolateral and apical ends of the cell that results in a segregation of function (Farr et al., 2009; Rodriguez-Boulan et al., 2005).
We speculate that the segregation of function on which the coherence of language depends breaks down.
Our data suggest that integral to this segregation of function is the segregation of proteins to different apical and basal compartments of the cell along the lines demonstrated in polarized epithelial cells.
Much more study is needed before we have a more comprehensive view of how the movement and segregation of transcripts function in cellular programming.
These findings are in agreement with previously reported effects of Numb and further confirm a function of Notch in the segregation of muscle sublineages [ 14],[ 32].
The concentration of multiple functions, however, is reflected in the functional segregation of the camps.
The above findings prompt the question of how does the cell segregation function of Krox20 relate to those of Hox proteins expressed endogenously in r3 and/or r5?
This may in turn impact on tissue segregation of mtDNA mutations disabling COX function.
Without Securin regulation, Separase is well regulated in all kinds of cells in vivo [30], [42] [45], whereas Separase functions poorly in PGCs without phospho-regulation, resulting in the premature segregation of sister chromotids and other chromosome segregation errors, including chromosome misalignment and mis-segregation.
By extension, rDNA copy number had no role in efficacy of meiotic pairing, segregation, centromere function, or viability.
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