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Using eQTL data from several sources, including the GTEx project, Geuvadis project, and TwinsUK cohort, we show that eQTLs in specific tissues tend to be most enriched among the predicted functional variants in relevant tissues in Roadmap.
However, none of these analyses addresses the question whether the increased mortality in ROADMAP was possibly a reflection of the J-curve relationship with BP.
The results seem to support the finding in ROADMAP; however, there are concerns regarding the credibility of the results of the Medicare study because of the discrepant findings in diabetics and non-diabetics.
Histone marks in Roadmap Epigenomics datasets were considered if overlapped significantly with our RNA-Seq data.
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From an academic perspective, a modular design approach in roadmapping contributes to more conceptual clarity, especially when providing roadmaps for a technology-driven innovation system with a core technology in the focus and multiple other competing or complementary technologies around.
These tasks are coded in a Roadmap Program written in ESL.
Earlier adaptations are possible and recommended (e.g., in yearly strategic meetings adaptations in the roadmap can be made).
Files were downloaded for annotations in primary melanocytes, keratinocytes, and fibroblasts included in the Roadmap Epigenome Project.
In Europe, the Biobanking and BioMolecular resource Research Infrastructure (BBMRI) was prioritized in the roadmap of the European Strategy Forum on Research Infrastructures ESFRII).
We summarize below the key points raised in the Roadmap.
Furthermore, SRS allows us to analyze all the paths in this roadmap simultaneously.
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