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We have recently found interaction between meat intake and polymorphisms in the ATP-binding cassette (ABC) transporter B1 (ABCB1, MDR1) which encodes glycoprotein P involved in reverse transport of carcinogens and other xenobiotic substances [ 20].
In parallel experiments in mouse striatal slices, cleaving STX1 with BoNT/C promotes a decrease in reverse transport of DA with a trend towards increased DA uptake.
These data present SCG neurons as a biologically relevant preparation in which to observe the functional role of STX1 in reverse transport of DA.
The molecular analyses provided in the paper by Cartier et al. (in press) elegantly demonstrate that alterations in reverse transport of DA may be involved in the pathogenesis of autism symptoms at least in the specific pedigrees.
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Amphetamines cause monoamine transporters to function in reverse, transporting these transmitters into the synapse (Koob and Nestler 1997).
In addition, ApoA-I participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase.
This protein participates in the reverse transport of cholesterol from tissues to the liver, thereby promoting cholesterol efflux.
Here, we show that hDAT R/W has reduced association with STX1, resulting in reduced reverse transport of DA and DA-related behaviors.
PPAR-β/δ is expressed ubiquitously and takes part in the reverse transport of cholesterol and the oxidation of fatty acids [ 15].
Apolipoprotein A1 (APOA1) is the major protein component of HDL in plasma and is believed to have a protective effect against atherosclerosis by participating in the reverse transport of hepatic cholesterol from tissues to the bile for excretion [ 10- 12].
The most widely accepted explanation for these effects is based on HDL's central role in reverse cholesterol transport (RCT), the transport of cholesterol from peripheral cells, like macrophages, to the liver for reuse or excretion as bile acids.
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