Sentence examples for in response to the mutation from inspiring English sources

Finally, the success of any computational approach for constructing genetic interaction networks is likely to be driven by parallel improvements in the experimental technologies, such as enabling measurement of phenotypic effects in response to the mutation of more than two genes in combination.

The role of Tyr80 was also underlined by other mutational analyses where kcat or substrate specificity was modified in response to the mutations designed at this site (Table 5).

Noteworthy was the subtle shift in the pH dependence of the coordination modes by ∼0.5 pH units in response to the A2V mutation.

In response to the M250 mutation, the DNA slightly pivots in the active site to relieve the steric compression between M250V and the +2 dNMP and L66/N65 as they move to fill the hole between M250V and Y203 and L66.

The cause of linkage disequilibrium is unknown and could result from either a partial selective sweep enabled by horizontal transfer of this genomic island, selection against recombinants driven by the presence of the indel mutation in this region of the genome, or some unknown molecular mechanism which may be inhibiting recombination locally in response to the indel mutation.

The metabolic load of producing hydrogenase apoproteins could contribute to the diminished growth rate, especially if they are overproduced in response to the ΔhydG mutation, but the hydrogenases were expressed in ΔhydG and ΔhydGΔech at the same level as in the wild type (CM Wilson, unpublished data), suggesting that metabolic load does not play a significant role in the growth defect.

Evidence from human and transgenic animal studies indicates that the degree of hypertrophy that develops in response to the causal mutation is modified by environmental factors (including demographic factors such as age, sex and body size), as well as by other genetic factors (Semsarian et al. 2001).

Although the IHC results argue that AKAP5 is indispensable for PKA anchoring to dendrites, changes in expression of other AKAPs or PKA might occur in response to the AKAP5 mutations.

Using next generation RNA sequencing, we mapped transcriptome and splicing target profiles of RBM20-iPSC-CMs and identified different cardiac gene networks in response to the analyzed RBM20 mutation in cardiac-specific processes.

This report provides the first comprehensive analysis of metabolite and transcript changes in response to the Li 2 mutation in elongating fibers.

Among these genes, Plxdc2 showed the strongest level of reduction in response to the combined oncogenic mutations.