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Importantly, HER2Δ16 employs a novel mechanism to upregulate BCL-2 protein levels in response to suppression of ERα activity.
Reduced invasiveness in response to suppression of Notch signaling and HES1 activity implicates Notch/HES1 signaling in metastasis [ 28].
Postnatal mouse models infected by intraventricular MCMV injection showed delayed cerebellar development with decreases in granular neuron proliferation and migration 40 and improved development of MCMV-infected cerebellum in response to suppression of inflammation by glucocorticoid treatment.
Studies with this culture system using the live autophagy marker Cyto ID, which specifically labels autophagic vesicles, demonstrated the induction of autophagy in real-time in response to suppression of either MAPK/JNK or MTOR signaling (Fig. 9J).
Likely contributing factors include saturation of the intracellular RNA interference machinery or induction of gene expression by activation of compensating pathway members in response to suppression of others (known to occur among the pocket proteins as well as among the p53 pathway members).
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Similarly, CDKN2A, was up-regulated in MCF-7 in response to p70S6K suppression but not with inhibition of mTOR.
In response to the suppression that began in 1999, Falun Gong was driven underground, the organizational structure grew yet more informal within China, and the internet took precedence as a means of connecting practitioners.
We found that the expression levels of the GABAAR α1 and β3 subunits, which are the major units of GABAAR in ES cells, were significantly up-regulated (Fig. 7A) in response to the suppression of BNP in ES cells.
10.7554/eLife.04378.018 Figure 7. Intrinsic excitability is increased in response to activity suppression.
EGFR upregulation in response to BRCA1 suppression was mediated by transcriptional and posttranslational mechanisms.
Three genes— NKD1, LEF1, and DKK4 were significantly downregulated in response to PITX2 suppression.
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