Sentence examples for in response to mutations from inspiring English sources

One reason for design failures is conformational plasticity, as proteins frequently change their conformation in response to mutations.

Consistent with a unique origin for pediatric low-grade glioma, third ventricle, but not lateral ventricle, NSCs hyperproliferate in response to mutations characteristic of childhood glioma.

We found that compensatory autophagy was induced in response to mutations affecting the proteasome and in response to UPS impairment in a fly model of the neurodegenerative disease spinobulbar muscular atrophy.

The precise spatiotemporal expression of Shh in the limb bud is perturbed in response to mutations within the ZRS.

Eliminating HSF1 in mouse models has extraordinary consequences on tumour formation and survival in response to mutations in known drivers like Ras and p53.

Canalization implies a reduction in trait variability [ 1, 3], i.e. in the propensity to vary in response to mutations or environmental changes [ 5], whereas it leaves genetic variability unaffected, allowing for cryptic genetic variation to accumulate [ 6].

By contrast with the native state, however, the intermediate ensemble is flexible enough to change in response to mutation, its structural properties being tailored by residues in the sequence encompassing the native helix III.

Similarly, e-h represents interactions of least active compound within binding pocket of wild type and mutated proteins to show how the compound 46 lost its interactions and activity due to conformational change occurred in response to mutation.

Utilizing this global analysis approach, the perturbations on the global stability in response to mutation can be partitioned between the monomer folding and association steps, and the effects of mutation on the populations of the folded and unfolded monomeric states can be determined.

We used the physical property distance to predict which amino acids are most variable in response to mutation bias.

LGG-1-II also accumulates in response to mutation of autophagy genes involved in autophagosome formation, including in UNC-51/Atg1 kinase complex mutants, VPS-34 PtdIns3P lipid kinase complex mutants, and in atg-18 and atg-9 mutants.