During reversible oxygen binding, the oxygenated form of myoglobin or hemoglobin is easily oxidized to the ferric met form in response to the generation of reactive oxygen species (ROS) [6], which are toxic to living organisms.
The mitogen-activated protein kinases (MAPKs), p38 and JNKs, have been implicated in apoptotic signaling in response to increased generation of ROS.
The H+ well was defined as an H+-conducting crevice passing down into the membrane dielectric and able to accumulate H+ in response to the generation of either Δ ψ or ΔpH.
We suggest that edaravone and possibly other radical scavengers or antioxidants should be administered in response to ROS generation, meaning that the bedside monitoring of ROS could shed more light on the potential benefit of these agents.
Similarly, heat-shock protein HSPA1B/ HSP70 expression was modified in lymphocytes from arsenic-exposed individuals from Bangladesh, as well as in several animal and cell culture studies, probably in response to the generation of reactive oxygen species (Andrew et al. 2003, 2007; Han et al. 2005; Liu et al. 2001).
A major part of this experiment was to quantify phenotypic and genetic changes in response to five generations of size-selective harvesting in wild zebrafish (Danio rerio) in the laboratory using functional genomic markers that can occur close by, within, or in the regulatory areas of genes under selection.
Imine formation and carbamylation was observed on the N-terminal proline in response to MPO-dependent generation of hypochlorous and hypothiocyanous acid, respectively.
Thus, ezrin reorganization occurred on similar time scales in response to both force generation and EGF stimulation.
Thus, in Src-transformed fibroblasts, invadopodia formation is initiated at adhesions in response to the focal generation of phosphatidylinositol-3,4-bisphosphate.
The C5aR receptor is regulated by the neutrophil serine protease (NSP), which cleaves it in response to excess C5a generation or necrosis [ 89].
