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We also showed that PAR1-deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR1-specific agonists and inhibitors were used to demonstrate that PAR1 mediates factor Xa signaling in human fibroblasts.
Initiation of the coagulation cascade and the subsequent production of proinflammatory cytokines (particularly in response to factor Xa (FXa)) are central to the pathogenesis of sepsis [ 9, 10].
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This, he added, meant that the product mix could be rapidly altered in response to factors like the price of fuel and the regulatory climate.
Additionally, vitamin D conditioning reduced expression of IFNα-regulated genes by healthy donor and SLE MDDCs in response to factors in activating SLE plasma.
It may be that transplanted pluripotent stem cells differentiate into the cell type of the local environment in response to factors secreted by those cells/tissues.
Both, the phosphorylation status of VE-cadherin and the composition of this protein complex are altered in response to factors interfering with vascular barrier function.
Nevertheless, it is potentially significant to note that multiple studies have shown that chromatophores differentiate and undergo apoptosis in response to factors that control chromatophore motile responses, that is, the redistribution of pigment organelles within chromatophores (see Sugimoto, 2002).
Our results demonstrate a significant 17% increase in myoblast migration in response to factors released from myoblasts undergoing stretch (Figure 5A) that was abolished when myoblasts underwent mechanical stretch in the presence of captopril (Figure 5B).
In the current study, we report key pro-inflammatory cytokines, associated with sepsis syndromes, as being induced in response to factors regulated by the S. aureus two-component gene regulatory system, saeR/S.
CRP is synthesized by the liver in response to factors released by macrophages and adipocytes.
Also, residual variances are reflective of individual variances in response to factors such as the intervention [ 48].
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