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Specifically, the composite matrix revealed a one order of magnitude increase in the shear storage modulus at compressive strains > 0.8 in response to compression compared to the mechanical features of individual components.
The cryogels with open interconnected macropores had a superfast swelling rate and a high swelling ratio, as well as high elasticity in response to compression.
Fibrin clot softening in response to compression strongly correlated with fiber buckling and bending, while hardening was associated with fibrin network densification.
According to our fluorescent immunocytochemical analysis, immunoreactivity of MuRF1 was found to be unchanged in muscle in response to compression.
Tissue texture variations were represented as altered compliances (inverse of stiffness) in response to compression of the back surface by the palpating fingers.
To our knowledge, only two studies have attempted to monitor cartilaginous extracellular matrix gene transcription by chondrocytes in 3D culture in response to compression [ 3, 27].
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Since diffusivity and partitioning can influence pericellular concentrations of bioactive solutes, these observations support a role for perturbations to solute transport in mediating the cartilage biological response to compression.
We observed an up-regulation of cFos and cJun mRNA levels as a response to compression, in accordance with the mechanosensitive character observed for these two genes in other studies using cartilage explants submitted to compression.
A similar structural response to compression has been observed in the trabeculae of cancellous bone [ 29].
These studies provide cues for the potential signaling pathways in response to mechanical compression by these mechanosensitive effectors.
Our results demonstrate a clear role for the PCM in interfacing the mechanical signalling in chondrocytes in response to dynamic compression.
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