Sentence examples for in repeated doses from inspiring English sources
Furthermore, a recent systematic evidence review found that global risk information, in repeated doses or with repeated counseling, reduced predicted CHD risk by 0.2 to 2 absolute percentage points [ 36].
The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied.
It is administered orally, in repeated doses, usually as the citrate salt.
When drugs are given in repeated doses, a steady state is achieved: the amount being administered equals the amount being excreted or metabolized.
If dehydration is so severe as to cause shock (severely decreased blood pressure with insufficient blood supply to the body's organs), or a depressed level of consciousness, rapid infusion of saline (1 liter for adults, 10 ml/kg in repeated doses for children) is recommended to restore circulating volume.
A 5-year-old child was erroneously given glipizide in repeated doses over 3 days [ 47].
In repeated dose, the 28- day oral toxicity study, NK was administered at 300, 600 and 900 mg/kg b.wt./p.o/day./p.o/day
Formation of the toxic metabolite acetaldehyde, which is the proximal toxicant, would subsequently lead to liver fibrosis through ROS (reactive oxygen species) formation in repeated dose in vivo studies (Landesmann et al. 2012).
Mice bearing Capan-1 tumours were given a single administration of rucaparib either by the i.p. route at a dose of 10 mg kg−1, the dose previously shown to be active in repeated dosing schedule (Drew et al, 2011), or orally at 50, 100 or 150 mg kg−1.
In general, repeated doses will have progressively greater effect and, in addition to extending the duration of surgical anaesthesia, can prolong the sleeping/recovery time following anaesthesia.
In general, repeated doses of anaesthetic drug will increase the depth and duration of the anaesthesia state, which could potentially prolong the recovery time.
