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Under physiologic conditions, large molecules, such as proteins and colloids, cannot cross the barrier in relevant amounts, which is a necessity for the regular function of circulation.
Importantly, T cells in culture with lowGM-DC and restimulated with anti-CD3 did not produce IL-2 or IL-10 in relevant amounts, only little IFN-γ (Fig. 4C).
Sulfate and β-hydroxybutyrate, on the other hand, though present in relevant amounts in serum, did not contribute to the change in SIG associated with hemorrhagic shock.
S100A12 and MPO are exclusively expressed in relevant amounts by granulocytes, which play an important role in the pathogenesis of IBD in humans [ 15, 34].
These were chosen because they have similar physicochemical properties to the arachidonate oxylipins, and they do not occur biologically in relevant amounts.
As for why heterotypic neutralizing antibodies do not prevail over homotypic neutralizing antibodies, and why they are not produced in all individuals in relevant amounts to provide protection remain open questions.
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NO has been known for more than two decades as a very effective platelet function inhibitor, but the search for drugs able to release it in vivo in biologically relevant amounts without incurring in untoward effects has been so far unsuccessful elusive (23).
One widely studied non-pharmaceutical alternative for promoting postmenopausal bone health is isoflavones; among commonly consumed foods, they are found in physiologically relevant amounts only in the soybean and soyfoods.
Recently, we have suggested 227Th as a novel radionuclide for alpha-particle radioimmunotherapy (RIT), as this radionuclide can be produced in clinically relevant amounts from β-decay of the long-term generator 227Ac [5, 6].
Our functional studies are also the first to show that nCB administered to the lungs in pathophysiologically relevant amounts can induce sterile inflammation and emphysema that is indistinguishable from disease induced by exposure to cigarette smoke in mice.
The availability of human GDAsBMP, which can be readily produced in therapeutically relevant amounts, also provides the first opportunity to harness the beneficial properties of astrocytes in treatment of CNS injury.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com