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In this case, the mutation in the PALB2 gene was linked to a deficiency in the DNA repair mechanism [ 27] and this could be targeted by mitomycin C. The obvious challenge in relation to this approach is to develop a systematic form of analysis in which a bioinformatics-assisted pipeline can rapidly and effectively analyze genomic data, thereby identifying targets and treatment options.
In relation to this, a strategy for tackling the challenges of chronicity was published in 2010 in the Basque Country [ 5].
Two main challenges exist in relation to this issue.
This is best understood in relation to the challenges of the alternative polypharmacy.
This has long been recognized in relation to the challenges presented by the physician patient relationship and is, increasingly, also the case in public health programs (Beauchamp and Steinbock 1999; Dawson and Verweij 2007; Jonson 1998).
When the results of this study are published we will discuss the findings in relation to the challenges and constraints of delivering and evaluating complex interventions, highlighting the difficulties of attributing inputs to outcomes and measures of impact.
These findings are discussed in relation to the challenges in diffusion and acceptance of decision-aiding automation.
And £140m is a lot of money, but not a great deal in relation to the challenges facing children across the country," he replies.
"The girls, in an ironic kind of way, went to some really good places yesterday in relation to the challenges they will face next year.
We were able to show a significant transgenerational transmission of behavior, which seems to be adaptive in relation to the challenges experienced by the parents.
The findings from this study are similar to several other studies conducted in the past in relation to the challenges caregivers go through when caring for persons with MDs (40– 40).
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