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Our discussion extends to both methodological issues in relation to study design and to pragmatic issues relating to the execution of RCTs.
There was significant heterogeneity between studies in relation to study design and laboratory methodology, complicating direct comparisons.
To study treatment modalities for cesarean scar pregnancies (CSPs), focusing on efficacy and complications in relation to study quality.
Nine were considered relevant and evaluated in relation to study design using a standardized study checklist and levels of evidence.
We identified significant sources of potential bias in both directions in relation to study design and implementation fidelity that have not been quantified previously.
The rate ratio of breast cancer associated with ever use of HRT was evaluated in relation to study design, study period, country, primary study objective, method of exposure measurement, age control, adjustment factors related to reproduction and menopause, and the presence of breast cancer surveillance.
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However, there is significant overlap in the systems that were manipulated in relation to studying the phenotypes individually.
This is why it was argued that observational studies have a limited role in relation to studying weak effects (Taubes 1995).
This is of interest in relation to studies on the E × B instabilities, as, for instance, the hydrodynamical Kelvin-Helmholtz (KH) instabilities and the ion temperature gradient instability.
Despite the isomorphic pressure, substantial variations across regions were found regarding internal and external validity, especially in relation to studies undertaken in Asia.
The evidence was explored in relation to studies employing measures of trait impulsivity (in self-report format) and studies exploring impulsivity with behavioural paradigms.
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