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The regulation of PPARγ by leptin seems complex in that it varied in relation to dose in vivo, and may be impacted by in vitro vs. in vivo circumstances.
The challenges that obese patients present to radiology departments, particularly in relation to dose reduction, are now increasingly recognised [15] because more than 30% of US adults and almost 20% of European adults have a body mass index of greater than 30 kg/m2 [17, 17].
The key research questions in tissue reactions and biological risk research are: Knowledge of the dose dependence of the radiation induction of primary or secondary cancers, in particular in relation to dose inhomogeneities and dose rate, is of major importance to optimise therapeutic efficiency and reduce unwanted side effects.
The phases of dependence can be defined by different clinical characteristics in relation to dose, administration route, and length and pattern of cocaine use.
Although we investigated response in relation to dose (3, 5 or 6%%), the studies did not provide data on frequency or duration of HS, which may also have varied across studies.
Placental transfer rates of cadmium were investigated in rats in relation to dose (0.1, 0.4, and 1.6 mg Cd/kg) and the gestational age (12, 15, and 20 days) when rats were treated.
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The absence of an effect on CSF Aβ peptide levels was consistent with the findings in the phase II trial [ 17] and may have been related to the small numbers of lumbar punctures and their timing in relation to dosing [ 7, 17].
Agreement of the INR measurements was further assessed in relation to dosing decision.
Furthermore, the KEDRF can be used to compare the dose necessary to elicit the key event(s) in relation to doses actually experienced in real-world exposures.
To effectively analyze such key events, a refined context of the dose necessary to elicit them is needed in relation to doses actually experienced from real-world exposures.
In the described case study, elimination of the drug through extended dialysis sessions (through adjustments to frequency and time in relation to dosing) aided tolerance and preservation of RRF.
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