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Multiparameter analysis of apoptosis in relation to cell cycle position is helpful in exploring mechanism of action of anticancer drugs that target specific molecular cogs of the cell cycle.
The availability of the Fucci system for the analysis of tumor biology and cell biology in relation to cell cycle regulation has been reported.
Our study suggest that other partners of the intracellular metabolism of gemcitabine in relation to cell cycle effects and DNA repair could be more responsible for the radiosensitising effect of gemcitabine than dCK activity of the cell.
The effects of 5-fluorouracil (5-FU), doxorubicin and paclitaxel on FDG and FLT uptake were measured in MDA MB231 human breast cancer cells in relation to cell cycle distribution, expression and enzyme activity of TK-1.
The detailed mechanism by which survivin influences cell fate following TGF- β treatment requires further study in relation to cell cycle status and regulators, the chromosomal passenger complex with Aurora B, microtubule dynamics, and caspase activity.
Because of the uncertainty about the relative importance of genetic and epigenetic mechanisms, we investigated potential effects of furan on gene expression in relation to cell cycle, apoptosis, and DNA damage, and we assessed potential changes in DNA methylation and microRNA (miRNA) expression.
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This is evaluated in relation to cell-cycle response and repair of ICL damage using DNA-repair-deficient Chinese hamster ovary (CHO) cell lines and human cervix carcinoma (HeLa) cells.
Future polychemotherapy protocols might position TRAIL in close relation to cell cycle in order to gain highest antitumor efficiency by TRAIL, based on the molecular understanding of drug drug interactions.
Gene selection was performed as described above, either by strong expression in RNA-seq (RPKM > 35) or by functional relation to cell cycle and senescence pathways.
A careful examination of the subcellular distribution of FBPase in relation to the cell cycle phases revealed that the enzyme localizes in nuclei of the KLN-205 cells positive for CycA and CycB1.
The precise molecular mechanisms and the role of fascin expression in relation to the cell cycle of NSCLC still remain to be explained.
More suggestions(15)
in relation to cell size
in relation to cell type
in relation to cell expansion
in relation to cell status
in relation to life cycle
in relation to cell death
in relation to cell migration
in relation to cell invasion
in relation to cell surface
in relation to cell growth
in relation to cell survival
in relation to cell density
in response to cell cycle
in relation to cell body
in relation to cell function
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