The scale of the trial and the need for long-term follow-up presented a number of design challenges in relation to obtaining consent, ascertaining and contacting participants who developed breast cancer, and collecting outcome data.
As case control studies generally do not allow interpretation of a cause-effect relationship, further research should include prospective evaluation of PPI users and NSAIDs users monitoring the development of IBS-symptoms in relation to drug exposure to ascertain whether this increased exposure to PPIs and NSAIDs should be considered as legitimate etiological factors in IBS.
Although this process relies on an interpretivist approach, the codes were re-examined in relation to the quantitative data to ascertain proximity to the research questions and provide an arguably meaningful interpretation of the interview data.
The themes were reflected on in relation to the naïve understanding to ascertain whether or not they validate or invalidate the naïve understanding.
Globo said: "A committee of the board has initiated discussions with appropriate advisers in relation to the next steps and to ascertain the true financial position of the company".
Other limitations were the lack of active comparator and microbiological data; thus, effectiveness in relation to microbiological eradication was impossible to ascertain.
Therefore, it is important to investigate the bacterial species implicated in the metabolism of dietary polyphenols, and further research is still needed in relation to the resultant microbial metabolites to ascertain their mechanisms of action.
Even if studies like ours are not available for each outcome measure and in relation to every population, professionals should ascertain the validity of the chosen outcome prior to the intervention.
As for all high-quality, protocol-driven research, we recommend that the statistical analysis plan of a prognostic marker study should be specified in the study protocol and include details of how the independent prognostic importance of the marker will be ascertained in relation to existing markers of clinical importance.
Apart from the obvious limitations of VA in any context, its use in relation to maternal mortality depends crucially on ascertaining pregnancy status reliably in the VA interview.
