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In contrast to vertebrate blood, the honey bee hemolymph has relatively high concentrations of inorganic ions, amino acids, sugars, proteins, and many other substances, but its contents are varied in regards to developmental stages, sex, and season [ 6, 7].
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This unique incident enabled us to explore infancy as a critical period of arsenic exposure in regard to developmental neurotoxicity and its possible persistence through adulthood.
Due to the differences in biochemical effects, these compounds seem to exhibit a range of different potencies in regard to developmental neurotoxicity.
In regard to developmental neurotoxicity, much information has in fact been published, although mainly as short reports in Chinese that have not been available to most expert committees.
In regard to developmental methylmercury exposure, we have previously discussed that the temporal windows of susceptibility may differ between different domains of brain function [ 23].
Given the likely importance of pesticides in regard to developmental neurotoxicity in humans, this review focuses on pesticides approved for current use in Europe, i.e. either authorised or being evaluated for authorisation within the European Union (Table 1).
Concerns in regard to developmental neurotoxicity due to pesticides have been fuelled by recent epidemiologic observations that children exposed prenatally or during early postnatal life suffer from various neurological deficits [ 7- 12].
The fact that no poisoning incident with neurotoxic effects has been reported for a given pesticide is of course no guarantee that the pesticide is not neurotoxic, especially in regard to developmental exposure.
This conclusion reminds us of the unfortunate advice another group of toxicology experts gave more than 20 years ago in regard to developmental toxicology: "Differences in sensitivity between children and adults are chemical specific and must be studied and evaluated on a case-by-case basis" [ 5].
In order to establish whether this does indeed reflect resolution of bivalent domains, we have assessed the presence of these marks both individually ('H3K4me3 only' and 'H3K27me3 only') and in combination (H3K4me3 and H3K27me3) with regard to developmental expression status.
The shift from external to local control over a project, however, will inevitably increase the variation and scope of project impacts, especially with regard to developmental impacts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com