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Blocking of NF-κB activation also resulted in reduced level of TNFα-induced optineurin protein level (Fig. 4D).
Our data revealed that HB-EGF treatment results in reduced level of Runx2 protein in a time-dependent manner (Supplementary Figure S9), possibly resulting from the upregulation of Shn3.
In ER-positive cancer cells, treatment with these compounds (except 50 μM I3C) resulted in reduced level of histone/DNA fragments in comparison with control untreated cells (0.45 0.80-fold change, Fig. 5d).
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Furthermore, this resulted in reduced levels of β-catenin in the nucleus, reduced TCF/LEF reporter activity, and decreased AXIN2 mRNA levels as demonstrated in U2OS cells.
Cell culture in 3D resulted in reduced levels of MMP1 and MMP9 secretion in PC3 cells.
In contrast, deleting gcn5+ resulted in reduced levels of MNase fragments of 600 bp or less, consistent with reduced chromatin accessibility in response to DNA damage (Fig. 5a c).
Mechanistically, this evolutionary NS1 mutation promotes the binding of NS1 to TBK1, resulting in reduced levels of TBK1 phosphorylation and IFN-β expression.
Woolley, A. G. et al. Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells.
If HIV-1 protease activity in virus producing cells is responsible for the activation of CASP3*, then the expression of Gag-pol, not Gag, should confer the cell growth disadvantage, resulting in reduced levels of Gag in these cells.
Treatment with thiostrepton resulted in reduced levels of the mitochondrial-encoded protein cytochrome oxidase I. Exposure to thiostrepton in combination with ATO resulted in a dramatic increase in cellular levels of reactive oxygen species (ROS).
Individuals with CF are known to have abnormal metabolism of fatty acids, typically resulting in reduced levels of linoleic acid (LA) and docosahexaenoic acid (DHA).
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