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The presence of intrinsic oscillations complicates the case of continuous inputs, because the impact of an input will depend on the phase at which it starts, as in recent phase resetting analysis for bursting models [18, 19].
In recent phase I and II studies testing this new compound in patients who had failed to respond to interferon (IFN), hematological and cytogenetic responses were reported in most of those with chronic-phase CML.
Positive results in recent phase III clinical trials have confirmed the high value of anti-angiogenic therapies for HCC in both first (sorafenib and lenvatinib) and second line (regorafenib and cabozantinib) treatment modalities.
The optimal pharmacokinetic profile and clinical features of SSTS in the treatment of acute postoperative pain have already been confirmed in recent phase II and III studies, in which the SSTS was administered as single treatment, and indeed our results are in agreement with data in literature (Minkowitz et al., 2013; Jove et al., 2015; Melson et al., 2014; Ringold et al., 2015).
Existing product candidates have demonstrated considerable efficacy in experimental animal models and in clinical trial subjects; however, severe adverse safety signals that appeared in recent phase II and phase III clinical trials involving certain HBOCs have in part hindered further development and licensing.
In recent Phase II/III clinical trials of fixed-dose pyronaridine-artesunate (3∶1 ratio) conducted in Africa and Asia, efficacy rates in P. falciparum malaria at Day 28 were >99%, and the combination was generally well tolerated [23], [24].
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This task was similar to that used in recent phase-encoding studies of parietal cortex (with just one substantial difference, see below), in which subjects perform memory-guided saccades to different visual field locations [9], [10].
In recent phase-II trials, gemcitabine (GEM), a pyrimidine analogue, has been shown to be an active single agent therapy in BTC.
Pharmacologic vitamin C concentrations produced in animals by parenteral administration were reproduced in patients in a recent phase I clinical trial [16].
It is likely the same confounding effects of secondary therapy are obscuring differences in survival in the recent phase 3 bevacizumab trials.
Such a strategy was taken by Dunleavy and colleagues in a recent phase II study in which the efficacy of bortezomib was investigated in DLBCL [11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com