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For permutation testing, we randomly shuffled expression values for all mRNAs/miRNAs 1000 times and calculated the average weight of modules in random conditions.
We found that none of the average correlation coefficients in each random condition is higher than the average of correlations of 34 candidate hub miRNAs (r = 0.3095), and the maximum average correlation coefficient is 0.2732 in random conditions (see Figure 5(a)).
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The characteristic path length of the age-related miRNAs was significantly lower than that derived in the random conditions.
Nevertheless, both controls and PD patients minimized object roll more in the blocked than in the random condition (p<0.01).
Subjects in both groups were able to initiate a corrective response faster in the blocked than in the random condition (122±3 and 152±3 ms, respectively; main effect of Predictability: [F 1,195) = 60.38], p<0.01; no main effect of Group, p>0.05).
No significant modulation of contact points to object CM location was found within the PD group in the blocked vs. random conditions (Fig. 2A, 2nd column).
Consequently, we predicted that PD patients would exhibit similar digit placement in the blocked vs. random conditions and produce larger peak object rolls than that of control subjects.
This deficit would be revealed by PD patients exhibiting similar digit placement in the blocked vs. random conditions and produce larger peak object rolls than that of control subjects.
The post hoc analysis revealed a significant difference between blocked and random conditions in the control group for the index and middle fingers when the CM was on the right (Fig. 2A, 1st column, p<0.01).
Controls lifted the object at a higher velocity than PD patients in the blocked condition (0.61±0.03 m/s vs. 0.54±0.02 m/s, respectively) and in the random condition (0.62±0.02 m/s vs. 0.50±0.02 m/s, respectively; p<0.05 for all post hoc comparisons).
In the random condition, both subject groups used a similar distribution of contact points across trials regardless of object CM location.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com