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This positive feedback process may be critical in RA development.
Indeed, the three papers they mentioned discussed the role of obesity in RA development.
IL-7 is considered an important mediator in RA development [ 35].
However, so far, few studies have focused on the involvement of Wnt signaling in T cells in RA development.
Rheumatoid arthritis (RA), an autoimmune disease of unknown aetiology, affects approximately 1% of the adult population. 1 Genetic and environmental factors are thought to interact in RA development.
Therefore, HIF-1α is identified as a key player in the pathogenesis of RA and a potential therapeutic target in RA development.
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These findings provide a new mechanism for IL-1β in synovitis during RA development.
Persistent synovitis as a marker of chronic disease is also an outcome of interest in early inflammatory arthritis [ 10- 12], although RA development in itself is important to predict.
To confirm the in vivo observation, we conducted a series of in vitro experiments that mimicked the in vivo situation during RA development.
The good correlation has been seen between serum DPPI levels and the severity of arthritis during RA development in CIA rats.
This system was successfully used to study antibodies against citrullinated peptides in individuals prior to RA development [ 40].
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