We recently defined that the loss of effective immunity relates to the retardation in proper functioning of a highly complex network of hundreds of thousands of molecular signals between the biphasic response profiles of 2 biologically opposing arms, Yin (tumoricidal) and Yang (tumorigenic) properties of self terminating mechanisms of acute inflammation [6, 7].
Selenium also plays a key role in proper functioning of the glutathione peroxidase system, which has been linked to depression.
As DUBs are integral regulatory molecules of most of the cellular functions, it has high implications in proper functioning of the cellular machineries (elaborated in other reviews [ 20, 21, 23, 24, 93– 93]).
These are very beneficial in lowering the bad cholesterol level as they help in proper functioning of liver.
As evidenced by the large amount of studies carried out in this field, epigenetic mechanisms play a key role in the proper function of the male gamete, and alterations in these mechanisms can widely affect human reproduction.
It is possible that the lysine residue upstream of the YXXΦ motif in the G-CSFR may be important in the proper function of this motif.
And perhaps pleasure is an Improvement Indicator (Plato, Millgram 2000) or Good State Indicator (Millgram 1997, Damasio 2003, pp. 137, 314n1) in its proper function.
"Look, we're not going to ask you for your hard-earned money anymore … unless we can guarantee that money will be used in a proper function," White House budget director Mick Mulvaney said last month during a news briefing.
Indeed, consistent with the predominant ER localization of CLN6p, the vLINCL mutation appears to significantly impact the ER, strongly implicating CLN6p in the proper function of this important membrane organelle.
