The finding that AAV-mediated overexpression of mutant A53T αSynuclein results in progressive, time-dependent DA neuron loss in rats is consistent with our idea.
Hypoxia induced a progressive time dependent decrease in TJ proteins ZO-1, Claudin-4, and JAM-C proteins expression over control.
A progressive time-dependent reduction in the total number of BrdU-labeled cells was found in the dentate hilus (F4,28 = 6.184, p<10−3) (Fig. 4c).
The importance of brittle intact rock fracture in association with pre-existing rock mass damage is emphasized though a consideration of the processes involved in the progressive-time dependent development not only of though-going failure surfaces but also lateral and rear-release mechanisms.
Consolidation refers to a progressive, time-dependent stabilization process, which transforms short-term memories into relatively permanent, long-term memories.
Altogether, the results here reported indicate that DCX down-regulation starts very early after the onset of RA treatment, it is progressive, time-dependent, and irreversible.
The most enriched profile comprised 134 proteins showing progressive time-dependent downregulation, abolished by reverse transcriptase inhibitors (Cluster #35; p = 10−78).
5-dAzaC caused a progressive increase in the conversion of E1 to E2 in a time dependent manner in 5-dAzaC pretreated HT29 cells at 6, 8, 10 and 12 h of incubation.
We examined offspring at progressive time intervals, including some kept until natural death in old age.
A progressive significant concentration and time dependent inhibition of the average root number, average root length indicated the morphotoxic nature.
The results of real-time qPCR demonstrated a progressive time- and dose-dependent decrease in the levels of PPAR-γ1 and PPAR-γ2 mRNA, with a maximal >70% inhibition after 24 h (Fig. 3A and data not shown).
