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"in profound" is correct and usable in written English.
It is an adjective phrase that is used to add emphasis, usually when describing a feeling, emotion, or thought. For example, "She felt in profound sorrow when she heard the news."
Exact(60)
It is in profound trouble.
But technology will change the world in profound ways.
In profound sorrow we announce the death of Former Hon.
Italy has also, however, been a country in profound denial.
He brought out some patients in profound pulmonary failure.
Northern Mexico is, of course, a region in profound crisis.
"It will result in profound dislocation in days ahead".
"I think society is going to change in profound ways," she said.
The perception of majority status may influence the politics of the issue in profound ways.
It unlocks the spirit of the person who is being inspired in profound and unpredictable ways.
"Its mechanism, however, was and still is shrouded in profound obscurity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com