Sentence examples for in previously published phase from inspiring English sources

The study examined the efficacy of pegloticase in a cohort of 30 patients with severe gout (93% tophaceous) utilizing an every 3-week infusion regimen, rather than the every 2-week schedule employed in previously published phase 3 trials.

In previously published phase 3 trials (the Liraglutide Effect and Action in Diabetes [LEAD] Program), treatment with liraglutide produced substantial and clinically significant reductions in A1C and fasting and postprandial glucose (PPG) levels, with a low risk of hypoglycemia, and moderate weight loss (7– 10).

Based on the results of a small disease-oriented phase I investigation in patients with advanced pancreatic cancer (unpublished data), a lower dose of the latter drug (200 mg m−2) was administered as recommended (350 mg m−2) in two previously published phase I studies in other solid tumours (Ford et al, 2000; Stevenson et al, 2001).

However, in the current study, adding erlotinib to docetaxel/carboplatin resulted in an objective response rate of 52%; lower than that reported for docetaxel/carboplatin (59%) in our previously published phase III randomised trial (Vasey et al, 2004).

In a previously published phase 1A study we defined pharmacokinetics and a dose range of metronomic oral vinorelbine that can safely be given to patients with advanced cancer and provided clinical evidence of the antiangiogenic basis of this therapy [ 22].

In advanced gastric cancer, two previously published phase II studies have shown consistent results regarding the activity of biweekly oxaliplatin-5 FU/FA oxaliplatin-5 FU/FA

Table 3 summarises the results of our study in comparison with the two previously published phase II trials of oxaliplatin, FA and 5-FU as first-line therapy in AGC patients.

A previously published phase II trial in kidney cancer patients used bryostatin-1 at a dose of 25  μg m−2 administered as a 30 min intravenous infusion on days 1, 8 and 15 of a 28-day cycle.

The points in the graph were based on experimental phase diagrams and previously published phase diagrams for PEG 35 000 and DEX 500 000 (Supplemental Figure 2 in the Supporting Information), DEX 100 000, DEX 40 000, and DEX 10 000.

Results of this trial are consistent with previously published phase 1 vaginal microbicide studies among sexually abstinent populations in that GU AEs were common and generally mild.

These withdrawal rates are comparable with those observed in previously published extended phase III trials of efalizumab 15, 16 and compare favourably with the withdrawal rate of 28% observed in a 4-month trial of methotrexate treatment of 44 patients with psoriasis.