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In preparing this protocol a full systematic review and meta-analysis of previous work has been completed.
We followed the PRISMA-P guideline for preferred reporting for systematic review and meta-analysis protocols in preparing this protocol.
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The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/12/152/prepub The authors wish to acknowledge the administrative support provided by Ms Renae Deans (The University of Queensland, Brisbane, Australia) for her help in preparing the protocol.
Other preparatory work to prepare this protocol included preliminary clinical patient evaluation in a single elective orthopedic centre.
AH assisted in preparing the recruitment protocol and the ethics commission application.
EJL participated in preparing the experimental protocol, clinical diagnosis and sampling.
EJL and WYC participated in preparing the experimental protocol, clinical diagnosis, and sampling.
FWH assisted in preparing the study protocol and the manuscript regarding the aspects of radiation physics in the study.
CT and LSE assisted in preparing the study protocol and the manuscript regarding the (radio -biological aspects of the study.
LSC, TH and WH assisted in preparing the study protocol and the manuscript regarding surgical and quality of life aspects.
In preparing our interview protocol, we made one adaptation to the original model of Greenwood and Hinings (1996) [ 23].
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