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Some of them have already progressed to the level of phase II and pivotal trials, indicating that initial safety questions with EpCAM-directed therapeutic approaches have been successfully addressed in preceding phase 1 studies and that the assessment of clinical efficacy is now of primary interest.
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The VIP regimen was chosen as the standard arm in the German randomised trial since VIP had shown a high complete remission rate, no pulmonary toxicity and a very low relapse rate in a preceding phase II trial in patients with seminoma (Clemm et al, 1993).
In the letter Mr. Sabri said, "We reaffirm our offer of a further series of technical discussions in order to evaluate what was accomplished in the preceding phase and to consider how to deal with the issues on the basis of outstanding questions".
In the preceding phase of our research, an entry-level cyber-physical stroke rehabilitation system (CP-SRS) has been developed, with the aim of enhancing patients' overall engagement during rehabilitation exercises.
Two outcome sounds were mapped to the response that had produced that sound in the preceding phase (compatible trials), whereas the two remaining outcome sounds were mapped to responses that had produced another sound before (incompatible trials).
Regression analysis of the three QI intervention phases of the project showed that the rate of increase of HAART initiation during phase II, the prototype PHC learning collaborative was no different from that in the preceding phase (rate of additional patients initiated on HAART during phase I=3.6/month, phase II=3.3/month).
This was even the case with one of the physicians who more enthusiastically defended the "idea" of FMG in the preceding phase of the project: When we tell them: "Yes, but there are clients who are not cared for, they are waiting to see a physician.
Unlike in (a), there is no clear increase in probability when the second preceding phase is accounted for.
Each phase exploits the output of its preceding phase, while it produces appropriate output to be used in the next phase, and so on.
The third phase consisted in the analysis of information gathered during the two preceding phases by using the OECD-DAC criteria for the evaluation of humanitarian action.
Following entry to the study, a two-week non-treatment run-in preceded the 16-week treatment phase.
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