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Essence is not in potency in relation to being, but in relation to itself, as a totality constituted in being.
The former is the cause of the animality and the latter of the rationality of man; neither of them can exist in man without the other, and the cogitative soul is in potency in relation to the intellective soul (SN, part V, chap. 5, fol. 69ra; In De anima, book II, t. c. 23, fol. 48ra).
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This could be explained by different potency in relation to the recommended dose, and therefore might not influence the risk-benefit ratio.
The focus of most of the E-Screen studies carried out with xenostrogens in the past was on defining potencies in relation to endogenous hormones, and presumably for this reason, information about low-dose effects is scarce.
Also due to the fact that compounds of this substructural class were documented as adenosine receptor ligands [36], computational SAR studies were focused on the PDE10A data, where the variation in potency was rationalized in relation to the physicochemical properties of the compounds (which were computed by FAFDrug3, Additional file 1: Table S1) [40].
Thus, for this case, the higher potency of T-1249 in relation to enfuvirtide seems to correlate with its higher membranes binding to the blood cells, particularly the lymphocytic fraction, where the preferential target cells are included.
In an attempt to standardise the effects of the different estrogens in receptor-based assays, their relative estrogenic potency (REP) has been defined in relation to the effect of E2 in the respective assay (e.g. [23]).
The efficacy and potency of aleglitazar are discussed in relation to other dual PPARα/γ agonists, in context with the published X-ray crystal structures of both PPARα and γ.
And the issue is further complicated by the fact that the potency of urinary macromolecules increases inversely in relation to the prevailing ionic strength [ 26].
In short, the potency of top-down prior beliefs in relation to bottom-up sensory evidence is controlled by the relative precision of prediction errors as each level of the cortical hierarchy.
Dosages of specific glucocorticoid preparations often are expressed in relation to the potency of the most frequently used preparation; that is, prednisone.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com