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We analysed the pooling weights to explain the differences in pooled estimates.
Subgroups analysis observed variability in pooled estimates (Table 3).
The differences in these estimates are due to differences in inclusion of randomized trials in pooled estimates.
Five of the reviews examined changes in pooled estimates of effect size of mortality rates when meta-analysis was restricted to high-quality randomized trials [ 26- 30].
When three additional studies [ 13, 24, 38] using only taxane-containing NAC were included in pooled estimates (six studies, 152 patients in total), the MD did not change (0.2 cm; I = 0 %), but LOA were higher (+/−3.9 cm).
We assessed changes in pooled estimates of treatment effect over time and how these might have been influenced by decisions taken by researchers as well as by the availability of new trials.
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Therefore, there is too much uncertainty in the pooled estimates in the two subgroups to clearly distinguish between them.
Moreover, a published curve can be a fitted estimate of the real curve based on the initial values, and any bias resulting from this estimation will be included in the pooled estimates.
Even when significant heterogeneity is present, which increases the relative weighting of low-weighted zero total event trials in random effects analyses, the changes in these pooled estimates are still relatively small (see Figure 2).
Wilcox also found that telemedicine was associated with a statistically significant reduction in LoS (both in ICU and in hospital) however no studies involving paediatric patients were reported in the pooled estimates.
First, considerable heterogeneity was found in the pooled estimates.
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