There are some challenges that remain for these devices to be fully employed in point-of-care application, including the usage of cultured cancer cell line, the used of whole blood sample, and low throughput.
Since these devices often require a large number of cells from human and animal models, it reduces the likelihood for the patient and physician to receive the results quicker, which causes them rarely to be used in point-of-care application.
It is expected that this simple sensing methodology for DNA detection can find its utility in point-of-care applications.
Kefala and Demetriades also reported much lower detection limits for Zn using bi-coated glassy carbon electrodes or pencil-lead graphite (6 nM or 0.4 ppb), but the inability to microfabricate these electrodes has prevented their use in point-of-care applications.
In addition, the increased information content, including, for example, binding kinetics, obtained from modern measurement devices suggests they will be the standard platforms in point of care applications very soon.
"Rain-on-the-roof" and point force excitations are considered, and in the latter case uncertainty exists in the point of application of the force.
Currently, field-effect transistor (FET -based biosensors have been implemented in several portable sensors with the ultimate application in point-oFET -basedting (POCT).
This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics.
An origami-driven paper-based 3D microfluidic analytic is a useful platform with great potential for application in point-of-care diagnostics.
At the same time, our biosensor has some advantages including high sensitivity, disposable usage and low cost, which implies its great promising application in point-of-care testing of HbA1c.
