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The objective of this review is to summarize recent findings in this area, place them in physiological contexts, and provide likely regulatory schemes whenever possible.
For example, patterns, fibre compositions, and fibre anisotropy can be incorporated into biomaterial design to achieve seamless mechanical gradients in structure and resulting dynamic function, which would be particularly useful in physiological contexts.
It discusses how injectable nanocarriers may be designed to enable delivery of drug combinations that are long-lasting and target-selective in physiological contexts (in vivo) to provide safe and effective use.
This is a great advantage for studying glia, which is sensitive to environmental changes, both during postnatal development and in physiological contexts.
It will therefore be interesting to monitor the expression of these genes in physiological contexts such as tree defence signaling during biotrophic or necrotrophic pathogen infections, or adaptation to environmental stresses.
Examination of this process in physiological contexts such as dietary restriction/overfeeding or following exercise would allow the precise role of SIRT3 in mitochondrial regulation to be fully elucidated.
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Therefore, in vivo RNAi HTS assays as described in mice (Beronja et al., 2013; Fellmann and Lowe, 2014) are likely to become an essential technology advance that facilitates gene function identifications in physiological context.
We next took genetic approaches toward identifying molecules that mediate metformin healthspan benefits in physiological context.
Also, isoform-specific targeting has been performed only in few cases to gain insight into how the function and expression of the protein isoforms differ in physiological context [4], [8], [9].
In order to determine the functions of the identified phosphosites and the PRR of M2 in physiological context of latency in vivo, we generated MHV-68 recombinant viruses in which the m2 gene was modified to contain the mutations in either the phosphorylation motif or the PRR (designated vM2P2, with proline residues at positions 158, 160, 163 and 167 mutated to alanine).
Hence, these data suggest that TAp73 regulates nucleotides metabolism in-vivo, in physiological context.
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CEO of Professional Science Editing for Scientists @ prosciediting.com