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The thawed LECs were propagated for at least 6 7 passages without alterations in phenotype and function.
However, the cell types produced using this approach are predominantly fetal-like in phenotype and function, limiting their use in regenerative medicine.
Most likely, a small heterogeneous population of antigen-presenting cells is present in uninflamed corneas which undergo changes in phenotype and function during corneal inflammation [6],[6]]-[6]].
Tumor vascular endothelial cells were inevitably defective in phenotype and function with remarkable variations between individuals.
To further confirm that TVECs were defective in phenotype and function, we examined expression of CD45, CD34, CD31 and VWF in the native human cervical and breast cancers.
However, a significant number of studies have shown alterations in phenotype and function of T cell subpopulations [13], [18], [19], [20].
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The results suggest that tumor cell-derived vascular endothelial-like cells were defective in phenotype and functions.
Some changes in phenotypes and functions of the immune cells in implantation site at maternal and fetal interface were reported in pathological conditions such as recurrent spontaneous abortions and preeclampsia [ 3– 7].
In this regard, one study indicated that CD4+CD25+ T cells were significantly decreased in patients with active SLE in comparison with normal subjects and patients with an inactive stage of the disease [ 67], and in another recent study [ 68] Treg were reported to be abnormal in number, phenotype, and function in patients with active SLE.
Second, increased ER stress might underlie pathological changes in cellular phenotype and function in IPF.
Dopamine induced ROS are most likely involved in mediating changes in monocyte/macrophage phenotype and function [ 58].
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