Exact(1)
These findings suggest that the EGFR-Ras-MAPK pathway is constitutively (but moderately) activated in compensation for the blockade of the HER2-PI3K-Akt pathway in GLM-1R cells, resulting in persistent growth in the presence of gefitinib and therefore acquired resistance.
Similar(59)
To determine the trailing effect in Candida strains (persistent growth of some isolates of Candida in drug concentrations above the IC50 after 48 h of incubation, commonly observed in broth microdilution tests with azole agents) visual reading was performed after 24 and 48 h of incubation.
In all 3 treatment groups, there was an apparent and persistent growth in the population of CD4+CD25− cells, with an overall increase of 124%, 120%, and 131% in the level of these cells following the hCDR1, control peptide, and vehicle injections, respectively.
The results suggested that persistent growth in abnormal loan leads to a notable increase in the ratio of non-performing loan (NPLs) to total loan, with solvency found to be significantly negative in the long run.
Cells destined to produce metastases must survive in the circulatory system, and the distal events of initial seeding and persistent growth in the target organ are also highly inefficient.
Consistent with these observations, we found that βarrs-deficient cells do not respond properly to serum starvation, as shown by their persistent growth in low serum and their failure to enter in G0 phase, whereas they proliferate faster in high serum conditions (Figure 6).
For survival and persistent growth in the presence of a constant immune response and in an environment which is changing considerably over decades of infection, permanent adaptation of the bacteria is thought to be required [ 4].
The pie has indeed become bigger – largely the result of persistent growth in the emerging world – but it's been sliced up in unexpected ways.
The persistent growth in infections has underscored both the special dangers and challenges that AIDS holds for the region.
Early diverging land plants exhibit indeterminate (persistent) growth in their haploid gametophytic generation, whereas later diverging lineages exhibit indeterminate growth in their diploid sporophytic generation, raising the question of whether genetic machinery directing meristematic functions was co-opted between generations.
Ahlfeldt and Feddersen's [2] study on the HSR connection between Frankfurt and Cologne showed that the shock to access on small cities with exogenous connections to the HSR lines because of their location between the two stations created persistent growth in local per capita revenue, with relocation of jobs and population to those areas.
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