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There are many medically serious reasons for bad breath — including poor dental hygiene, gastric reflux, infections, bowel obstruction, diabetes, kidney disease and cancer — that should be ruled out in persistent cases.
In persistent cases, other reasons for hypercalciuria such as hyperparathyroidism should be excluded.
Recent neuroimaging findings have improved our knowledge about central mechanisms of OA pain, especially in persistent cases.
However, in persistent cases without readily apparent causation, assessment for potential medication toxicity may prove explanatory.
In persistent cases chronic infections occur, with patients remaining infectious and developing liver cirrhosis, hepatocellular carcinoma or both over a period of several decades [ 2, 3].
Both nodules and granulomas can be treated with triamcinolone local injection at first time or through a small incision in persistent cases (Zide 2003; Jacovella 2006; Jansen and Graivier 2006).
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A large number of pathophysiological mechanisms have been delineated, and there is general agreement that in many persistent cases several of them are operant in maintaining the pain.
In certain persistent cases, modern endodontic surgery may enable a minimally invasive and highly accurate surgical procedure, and with adequate case selection, may provide a predictable outcome and allow the preservation of the tooth.
Dose reduction and/or temporary interruption of regorafenib, or in severe or persistent cases, discontinuation of regorafenib should be considered (Table 3).
Nevertheless, regarding drug resistance, persistent cases in our study show characteristics similar to the relapse cases on the national level.
Ambrose et al. (1993) examined whether genetic transmission is different in persistent and recovered cases.
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