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Consequently, the sensory hair cells that receive sound information cannot be replaced, and their loss results in permanent hearing impairment.
An important question that logically follows would be why prestin, the crucial protein responsible for amplification of sounds, is involved in the process of apoptosis in OHCs, the consequence of which will result in permanent hearing damage.
Ototoxic drugs result in permanent hearing loss for over 500 000 Americans annually.
Auditory testing began at approximately PND 200 to determine if developmental exposures resulted in permanent hearing deficits.
Mammalian cochlear hair cells do not regenerate naturally, and hence damage to them can result in permanent hearing loss.
Unfortunately, humans and other mammals are unable to regenerate damaged hair cells, which results in permanent hearing loss.
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This time point was selected because we showed that injection of low gentamicin concentrations resulted in a permanent hearing impairment 7 days post treatment.
Of all sensory disabilities in early childhood permanent hearing impairment that originates from birth or in the neonatal period is of special interest because of its adverse consequences on speech, language, cognitive and psychosocial development and the subsequent impact on educational and vocational attainment when detected late particularly in developing countries [ 8].
These noise levels can cause major difficulties in speech communication, and permanent hearing loss in frequently exposed personnel.
The Navy estimates that loud booms from just its underwater listening devices, mainly sonar, result in temporary or permanent hearing loss for more than a quarter-million sea creatures every year, a number that is rising.
At certain levels and durations of exposure, it can cause physical damage to the eardrum and the sensitive hair cells of the inner ear and result in temporary or permanent hearing loss.
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