Sentence examples for in pel from inspiring English sources

An essential role in PEL cell survival is known to be played by NF- κB, constitutively activated in PEL cells due also to the effect mediated by KSHV-encoded viral FLICE-inhibitory protein (v-FLIP) expression [ 33, 34].

Removing these genes from the list of PEL gene dependencies identifies 210 genes that are specifically required in PEL but are unlikely to be housekeeping genes.

IRF4 is furthermore downregulated by treatment of PEL cell lines with IMiDs, suggesting that a dependency on IRF4 in PEL cells may be druggable.

In conclusion, this study demonstrates that intracavitary growth of PEL induces EMT in the mesothelium, and that this pathogenic mechanism may play a role in PEL progression.

Given that genes in the NF-κB pathway are individually non-essential in PEL cell lines, it is unlikely that this pathway controls the expression of the highly essential oncogenes IRF4 and MCL1 in PEL cells, although this has been observed in other cancers59,60.

The high rate of EBV co-infection in PEL tumors and increased tumor formation of KSHV and EBV co-infected B cells in mouse models point to a role for EBV in PEL pathobiology.

High levels of MCL1 expression in PEL tumor cells further support its oncogenic role and viability as a drug target in PEL.

Because IKZF1 has recently been reported as the relevant IMiD effector in PEL, the mechanisms of action of IMiDs in PEL require further investigation.

Thus, repurposing already available drugs is likely the most practical option for treatment strategies in PEL.

The role of vCYC expression during latency in PEL remains unclear.

In conclusion, our CRISPR knockout screens effectively identified genetic dependencies in PEL cell lines.