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Although we did not find significant changes in PBP serum levels of disease subjects compared to controls, the acid form of PBP suggests that the PBP mobility shift in 2D maps might be related to PBP post-translational modifications, e.g. protein phosphorylation state, more than to PBP quantitative differences (Table 3, Table S1) [34].
The simplified fabrication procedure has been utilized to reveal the fundamental electro-optical performance of both absorbers in pBp dual-band detector structure.
Among remaining 5 β-lactamase positive strains, one isolate had amino acid substitutions in PBP 3.
Alterations in PBP genes result in reduced affinity for penicillin and other β-lactams.
Many amino acid loci in PBP sequences of K. alvarezii were conserved with those of LL- Prochlorococcus.
Susceptible 19A isolates lacked mutations at key residues in pbp genes which are associated with β lactam resistance [ 14].
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Up to now, there has been no evidence that MinCD is involved in PBP-2B binding to the Z-ring.
In addition to the roles in PBPs assembly and energy migration, the chromophoric γ subunit is preferentially sensitive to the intense light, and probably functions in the photoprotection of PBsome.
Although the presence of PBPs per se does not confer resistance, chromosomal mutations in PBPs may render the bacteria resistant to β-lactams [ 72- 75].
Carbapenem resistance in Gram-negative bacteria can be the consequence of the production of a β-lactamase, expression of efflux pumps, porin loss, and alterations in PBPs.
These alterations were found to include three amino acid substitutions which were identical and were present in PBPs 1, 2, and 3.
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