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The researchers described how they developed a new way to induce the effects of obstructive sleep apnea in mice -- specifically, the closure of the airway that results in paused breathing and the physiological side effects of OSA.
Pyrophosphorolysis and NTP addition in paused complexes were performed as above.
Instead, they may be in paused states as the previous reports suggested [ 18, 31, 32].
However, a small fraction of poorly expressed and weakly paused genes show a reduction in paused Pol II after FP treatment.
We further predict, based on our observations of an increase in paused microtubules and slower EB1 binding and unbinding in the klp10A RNAi knockdown spindles, that KLP10A also has a role in EB1 unbinding from cortical microtubules in oocytes.
While a smaller fraction (∼20%) of genes displayed an unexpected decrease in paused and divergent Pol II peaks, these genes generally display lower levels of pausing and gene body transcription.
Similar(51)
He leaned in, pausing purposefully.
The MPC was justified in pausing the policy to try to see what is going on.
"For a profession in the rapidly changing media environment which we're in, pausing is not a good place.
NELFe binds to Pol II and is involved in pausing of the initial elongation [ 24].
By design, the approach was slow, with built-in pauses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com