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There were no differences in pattern of relapse between both groups.
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These have suggested a poor OS 14 and also suggested potential differences in patterns of relapse and outcome of EPSCC from differing primary sites, with breast, genitourinary, gynaecological, and head and neck tumours potentially more likely to present with localised disease, whereas gastrointestinal (GI) EPSCC is most likely metastatic.
Significant differences were seen in the pattern of relapse.
Furthermore, no difference in the pattern of relapse was found and also the number of nodal relapses was the same between the two groups (Table 5).
There were no clear differences in the pattern of relapses and, specifically, there was a similar number of retroperitoneal relapses between the two arms.
Additionally, node-negative and node-positive tumors show a different pattern of relapse in this early period, indeed almost all the recurrences in the molecular groups different from the high-proliferation/low-ERS group occur in node-positive cancers (P = 0.0008).
These are based mainly on the spatial pattern of relapse in retrospective and prospective studies, which report the majority of first local relapses close to the primary tumour site, and on the assumption that radiotherapy does not prevent the development of new primary tumours developing elsewhere in the breast.
Surprisingly, the pattern of relapse in JACLS cohort, 9 of 82 patients, was unique: eight of nine patients relapsed during the maintenance phase and one patient had primary induction failure.
The pattern of relapse in patients with locally advanced rectal cancer and the tolerability of treatment [ 37, 38] (Mawdsley et al, 2005; Rasheed et al, 2006) call into question the approach to preoperative intensification of chemoradiotherapy currently under investigation elsewhere.
However, the pattern of relapse was unique in the present study, especially in JACLS cohort: eight of nine patients relapsed during the maintenance phase and one patient had primary induction failure, suggesting that leukemic blasts in these patients initially showed resistance to the chemotherapeutic agents used.
The pattern of relapse detection in this cohort is very different from that reported in any of the cohorts we have analysed here.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com