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The difference in pattern of regulation of the virulence proteins identified suggests different regulation pathways.
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Finally, IGFBP3 was unique in its pattern of regulation and we further investigated a possible role for IGFBP3 down-regulation in ErbB2-dependent transformation through suppressed IGF1 signalling.
Hence, the change in the pattern of regulation can be represented as D_U_D* to indicate the regulatory pattern of hsa-miR-1 and CA3 in the healthy population and in ER+ breast cancer patients and ER− breast cancer patients.
As an additional test of the overall consistency in the pattern of regulation, we applied a sample randomization test and found as a whole the data set is highly structured (P < 1e-10).
In particular, the pattern of regulation of the growth-related mRNAs suggested that after the differentiation stimulus, the trypanosomes - which were already not growing - further reduced resources for cell division.
Studies in the field of evolutionary developmental biology have highlighted an important role for the divergence in patterns of gene regulation in shaping species-specific developmental outcomes.
For miRNA regulated in both microarray and qPCR, the pattern of regulation was similar in the two analyses when grouping all RSV positive children together.
Our analysis reveals the pattern of regulation in this central and highly regulated network, thus providing insights into the regulation strategy adopted by the bacteria.
The Slfn gene family is expanded in mice [7], and non-helicase-containing Slfn family members showed a similar pattern of regulation in macrophages (Figure 1).
Regarding cGMP, we could think that PDE1 and PDE5 may have a common pattern of regulation in cardiomyocytes.
Here, we report the in silico functional characterization of the "non-additive" proteins (the ones with a non-additive pattern of regulation) in synthetic B. napus.
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