Treatment with either BMP4 or TGF-β increases expression of contractile smooth muscle genes; this process is due, at least in part, to the miR-21-mediated repression of programmed cell death protein-4 (PDCD4).
This repression is attributable, in part, to the EWS/FLI upregulated target NKX2.2, and is mediated through HDACs.
We link CBX7 overexpression to suppression of both canonical and non-canonical Wnt signaling pathways, owing in part to transcriptional repression and associated DNA methylation of the LEF1 enhancer protein and cJUN transcription factor.
This increased lifespan was due, at least in part, to p16 repression by epigenetic chromatin remodeling and activation of SIRT1-mediated epigenetic and genetic regulation.
The high expression of Sp transcription factors is due, in part, to miR-dependent repression of the Sp repressors ZBTB10 and ZBTB4, which competitively bind GC-rich gene promoters and deactivate transcription [ 25, 26].
The loss of motility is due, in part, to repression of flagellar biosynthesis by the AlgT-dependent transcriptional regulator AmrZ [7] induced by the CF airway fluids [6].
The carcinogenic properties of nickel may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation status and histone tail post-translational modifications.
The shifts in gene expression we observed in psoriasis lesions are likely due, in part, to activation or repression of TF-mediated regulatory mechanisms.
In 1999, NATO undertook a campaign of airstrikes against Serbia, in part to end Serbian repression against Albanian civilians.
Suppression of reprogramming by miR-34a was due, at least in part, to repression of pluripotency genes, including Nanog, Sox2 and N-Myc.
