Such a redundant set of quality-control factors is a well-documented characteristic of cellular proteostasis, as seen for example in yeast, where the E3 ligases Ubr1 and San1 work in parallel, targeting unfolded proteins for degradation44.
Meanwhile, the online marketplace will be developed in parallel, targeting a higher tier market than other stock photo sites like Shutterstock or Getty, with pricing ranging from around $250 to $500 per photo – a market segment which Gutsol notes has no clear leader at this time.
In parallel, target cells were incubated alone to measure basal apoptosis.
Theoretically this could facilitate polyvalent vaccines containing more than one antigen in order to achieve in parallel targeting of a higher percentage of tumor cells in genetically heterogeneous tumors, or vaccines that can be used without prior antigen monitoring.
However, in parallel to targeting the catalytic domains of USPs for drug design, it would be advantageous to target individual substrate recognition, regulatory or protein interaction domains, as this would avoid concerns about cross-reactivity.
In parallel, fixed target experiments at the upgraded JINR superconducting synchrotron Nuclotron are carried out with the extracted beams of various nuclei species up to gold with the momenta up to 13 GeV/c for protons.
Therefore in holistic drug design approaches, where ADME T) properties are considered in parallel with target affinity, considerable efforts are focused in early estimation of PPB mainly in regard to human serum albumin (HSA), which is the most abundant and most important plasma protein.
In silico methods may be applied in combination with various in vitro and in vivo models to optimize the metabolic stability and, in parallel, the target activity of compound series [2].
Working in parallel to target different ends of the same spectrum, social enterprises and NGOs are now in a better position to effect global change than either of them could alone.
The HbRH2b gene was amplified in each reaction plate in parallel with target genes.
