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Indeed, FAP+ fibroblasts produced ECM fibers oriented in parallel patterns when compared to FAP- matrices.
Moreover, human pancreatic adenocarcinoma-associated fibroblasts produced ECMs oriented in parallel patterns, which are similar to the patterns formed by FAP+ matrices.
Since tumor-associated ECMs are organized in parallel patterns [ 21, 22, 37], we tested whether FAP expression affects the topography of fibroblasts-derived ECMs by indirect immunofluorescence using anti-fibronectin or anti-collagen I (Additional file 2, Fig. S2) antibodies on un-extracted matrices containing their original matrix-synthesizing fibroblasts [ 21].
In fact, it has been shown that both desmoplastic fibronectin and collagen I fibers often align in parallel patterns in response to tumorigenesis [ 21, 22], and these fibers are engaged by integrin heterodimers in pancreatic and other cancers [ 6, 20], suggesting that cell behavior can be affected by the underlying stromal substrates via integrin engagement.
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To find associations among entities, AliBaba uses two different techniques in parallel: pattern matching and co-occurrence filtering.
Based on available evidence from karyotype-phenotype correlations, the second difference may parsimoniously account, at least in part, for parallel patterns in phenotypic variation between Xmat versus Xpat Turner females, compared to males versus 46,XX females.
It follows that the more we can teach students to think in terms of parallel patterns, the more their thinking will resemble that of parallel software professionals.
Double-column plating using two 3.5-mm plates in orthogonal or parallel patterns is another option [7], but it requires greater soft tissue stripping and exposure, leading to a potentially higher non-union and infection rate and elbow stiffness reported in some series [5, 8].
As shown in the optical images (OM) images in Figure 3, the CNF with our solution shows no significant change in the morphology of the parallel patterns after immersion in deionized (DI) water at room temperature for the periods of 1 and 7 days, respectively.
In the parallel pattern, i.e., the pattern prevalent in the eastern German sample, job instability and the prospects of parenthood are interrelated in a less straightforward fashion.
FAP+ cells were elongated into an enhanced spindled shape, and they organized in a parallel pattern (data not shown).
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