The model addresses the trends in fast NSC primarily through combinations of NOx storage contributions in parallel pathways on Ba vicinal to Pt and Ba uninfluenced by Pt.
This argues against a global mechanism, such as a pathway-specific refractory effect, and suggests that stimulus processing is occurring in parallel pathways, some of which are not affected by temporal manipulations of matching-stimulus interval.
Remarkably, these effects were absent in TASK-3 mutants indicating that TASK-3 is either directly involved in the mechanism of this drug's action, or participates in parallel pathways that achieve the same effect.
We also provide genetic and phenotypic evidence to support the model that PHA-1, a novel protein, and UBC-18, a ubiquitin-conjugating enzyme that we have previously shown to function with lin-35 during pharyngeal development, act in parallel pathways to regulate the activity of a common cellular target.
Results reported in this study now indicate that Not4p and Bur1/2p act in parallel pathways.
The localization cues ITD and ILD are processed in parallel pathways in the brainstem [16] [18], where neurons are narrowly tuned to sound frequency (Reviews: [4], [5]).
The double-mutant not4S/T5A and bur2Δ strain even revealed enhanced phenotypes, indicating that phosphorylation of Not4p and BUR2 are active in parallel pathways for drug tolerance.
Paralogs may diverge in function to evolve roles in parallel pathways that control common processes but are employed in different contexts such as distinct tissues.
Alternatively, though not mutually exclusive, is the possibility that Elmo and Spg function in parallel pathways and our observed phenotypes are a result of these additive effects.
These observations are consistent with a model wherein the Ccr4-Not and Bur1/2 kinase complexes act in parallel pathways to regulate cellular stress responses.
One interpretation of the AND relationship is that Xi and Xj form a functional complex; an interpretation of the OR relationship is that Xi and Xj are in parallel pathways.
