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In our profiling, the decrease in the expression of this gene was accurately reproduced (Fig. 6).
Because SNL is a nerve injury model, it should not be surprising that, in our profiling of SNL-induced changes in DRG, miRNAs targeting genes involved in neurite outgrowth and axonal regeneration [47], [48] are downregulated.
In light of the known mechanisms of miRNA influence on gene expression, it is not surprising that we did not observe a strict inverse correlation between the differentially regulated miRNAs and their predicted mRNA targets in our profiling studies.
Furthermore, the miRNAs that showed aberrant expression in cardiomyocyte hypertrophy and/or cardiac ischemia/reperfusion (miR-15, -16, -21, -23a, -29, -30a, -150 and -195)[21], [21] have also been detected in our profiling data.
Four hundred such genes with selective adult astrocyte-enriched expression were identified in our profiling studies (Table S6).
In our profiling study, we confirmed the increased expression of miR-1 and miR-208 in AMI serum.
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