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Aside from its role in orienting of attention, the NBM cholinergic network has also been implicated in memory encoding.
Finally, the ascending noradrenergic network is also implicated in orienting of attention (Aston-Jones et al., 1999) and, as described above, this network degenerates progressively in PDD.
We focus on attention because the intraparietal sulcus, involved in number processing and possibly which is abnormal in those with developmental dyscalculia, has a critical role in orienting of attention [see [ 26]].
These activation results appear consistent with the present finding of intact functional connectivity between caudate nuclei and medial parietal cortex and may be linked to socio-emotional functions or to additional roles of the posterior cingulate in orienting of attention to a spatial cue [ 91, 92].
Two large placebo-controlled trials have shown that rivastigmine significantly improves deficits in orienting of attention, vigilance and cognitive fluctuation in patients with PDD (Emre et al., 2004; Wesnes et al., 2005 b ), and indeed patients with more severe attentional deficits appear to respond best (Wesnes et al., 2005 a ).
Conversely NBM lesions in animals have been shown to block this electrocortical activation (Buzsaki et al., 1988; Fuller et al., 2011), and cause impairments of learning and memory (Bartus et al., 1985; Mandel et al., 1989; Butt and Hodge, 1995; Leanza et al., 1996), as well as impairments in orienting of attention (Voytko et al., 1994; Voytko, 1996).
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Consequently, the main aim of the present study was to compare biases in initial orienting of gaze towards fearful versus angry faces in high- and low-anxious individuals.
This study compared biases in initial orienting of gaze to fearful and angry faces, which varied in emotional intensity, in high- and low-anxious individuals.
Biases in the orienting of spatial attention may be assessed reliably using the line bisection task, which is commonly administered to unilateral neglect patients and healthy controls.
In addition, cognitive models of anxiety predict that high-anxious individuals should show greater biases in initial orienting of gaze towards both angry and fearful faces, than low-anxious individuals.
The authors concluded that "elevated motivation leads to improved efficiency in orienting and reorienting of exogenous spatial attention" (Engelmann & Pessoa, 2007, p. 668).
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