In addition, many of these novel approaches are being developed both in monotherapy and as part of combinatory regimes in order to synergize their activity.
Four novel scaffolds consisting of total 24 compounds (1a 1o, 2a 2c, 3a 3c and 4a 4c) bearing aromatic sulfonamide and coumarin moieties connected through various linkers were synthesized in order to synergize the inhibition potential of both the moieties against four selected human carbonic anhydrase isoforms (hCA I, II, IX & XII).
On an international scale, community-based groups in different countries who find themselves fighting similar environmental problems can unite in order to synergize their efforts.
We demonstrate that another function of mitochondrial fusion proteins is to electrically couple individual mitochondria in order to synergize their metabolic activity.
* promote balanced and sustainable economic development in order to narrow development imbalances and reduce poverty.
As GATA3 and Notch were shown to synergize in order to promote Th2 differentiation, it is likely that GATA3 and Notch are recruited to the GATA3 and IL4 loci in a cooperative fashion by associating with each other.
This dose was also used to supplement conventional chemotherapy in order to discover whether it might synergize and shorten the required duration of chemotherapy.
The major TH2 cytokine, IL-4, that was initially reported to synergize with TGF β in order to induce IL-9 in CD4+ cells [ 83] appears to be but a second signal for the generation of TH9 [ 82].
In order to examine if the cell growth inhibition in neuroblastoma mediated by topotecan can be synergized with NF-κB pathway inhibition, we tested a specific NF-κB inhibitor, NSC 676914 [ 19] and a FDA approved proteasome inhibitor which also inhibits the NF-κB pathway, bortezomib, in combination with topotecan.
Therefore, PARP-1 could synergize with different transcription factors in order to stimulate or repress gene expression in both stimulation conditions.
