They can be stored over months, both hydrophobic and hydrophilic drugs can be encapsulated or adsorbed, they can be functionalized, and most importantly their physicochemical properties can be adjusted in order to achieve a controlled release of the encapsulated drug.
The intrinsic drug-loading capability of polysaccharide-based hydrogels and their potential use as drug delivery systems can be combined with more sophisticated techniques in order to develop effective approaches for controlled release of bioactive agents.
A model drug Propranolol HCl was incorporated in the formulation in order to assess the controlled release and time dependent release potential of various natural polymers.
In order to design a controlled release system with specified release characteristics, values of diffusion coefficient and solubility are required.
In this study we report on the incorporation of various pharmaceutical excipients into TMC 120 silicone, reservoir-type intravaginal rings (IVRs) in order to modify the controlled release characteristics of the microbicide.
In order to take advantage of controlled release implants of valproic acid, the drug was encapsulated into titania ceramic matrices via a sol gel process.
Using this technique, a stimuli-responsive controlled drug release has been developed in order to release bioactive agents.
Indeed, this could be incorporated in our future work for controlled release of our HMSNs by utilizing such different moieties.
In order to get a more controlled release rate of ibuprofen, a biodegradable oil, Labrafil® M1944CS, polyethylene glycol 300 derivative, was used as an additive.
In order to help in addressing it, we herein propose to use the controlled release of encapsulated nutrients within polymer microspheres into chitosan-based 3D scaffolds, wherein the microspheres are embedded.
