Km parameters and concentrations in units of mM In general, optimized values were close to initial values, however six parameters (vmax1, vmax2, vmax10, Km8, atp, and bc) changed by a factor of two or greater.
Initial lead structures are, in general, optimized in terms of affinity using iterative cycles comprising synthesis, biological evaluation, computational methods, and structural analysis.
Is flânerie still an appropriate model for today's impatient city walker, who travels in optimized, smartphone-dictated routes to her destination?
While maximizing (9) remains a challenging optimization problem in general, it may be optimized efficiently if the graph of clusters has a particular structure, e.g. if many nodes are isolated or if it contains no loop.
Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant parameters.
In this way, it is possible that outpatient treatment in general can be optimized, and that the frequency of necessary health care provider/physician/clinician and other clinical staff visits can be reduced and be more flexible according to the needs of the patients.
Mutation helps in generating optimized combinations.
In general, verifying optimized operation or fault tolerance over a general space of network architectures is an intractable problem.
In the general case, this optimization is applicable if different models are compared, where each of them is optimized iteratively.
The instances we used for this study are summarized in Table 2 and are chosen to represent several different categories such as economical, general, memory-optimized, compute-optimized, and storage-optimized cases.
It is however reasonable to assume that the functional form in Eq. (2) may render general for generating optimized SF networks.
