Sentence examples for in optimal context from inspiring English sources

Our genetic findings indicate that the E144R substitution in β-strand 1 of the hairpin reduces the rate of bulk translation initiation and dramatically impairs recognition of GCN4 uAUG-1 in optimal context by the scanning PIC, conferring a higher incidence of leaky scanning for the el.uORF1-GCN4-lacZ reporter than described thus far for any initiation factor mutation (Elantak et al., 2010).

We have also analyzed the sequences of 13,124 human mRNAs (RefSeq databank), discovering that in 6448 cases (49%), an in-frame stop codon is present upstream of the initiation codon, while in the other 6676 mRNAs (51%), identification of additional bases at the mRNA 5′ region could well reveal some new upstream in-frame AUG codons in the optimal context.

The identification of a more complete mRNA 5' end could reveal an additional upstream AUG – in-frame with the previously determined one and in the optimal context – thus extending the predicted amino terminus sequence of the product.

But they are likely to work even better in an optimal context.

AUGs matching the consensus at both of these sites are described as being in an optimal context, those matching at one are strong, and those matching neither are described as weak.

Similarly you can follow a checklist to create what Situations Matter author Sam Sommers calls the optimal context - in this case for your patients to view you as credible and caring.

Unlike the start codon of the main ORF, which in good initiation context is typically identified by the consensus Kozak sequence [ 21], many of the uAUGs are in sub-optimal context for translation [ 16].

These reporters contained an AUG start codon in optimal Kozak sequence context immediately upstream of the 70 G4C2 repeats and lacked the UAG stop codon that natively occurs in the GP reading frame immediately upstream the repeat (Fig. 2a).

One major issue surrounds the identification of the best animal model to understand how the LR axis is established in humans, in order to study human laterality diseases in the optimal biological context.

The data in this article remind us that, in an optimal sequential context, even a speaker with a severe aphasia can achieve much in terms of taking a turn at talk.

Their findings revealed that mutations in rps5 resulted in a decrease in AUG recognition for start codons that were not in the optimal sequence context.